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- W2359355557 abstract "Cardiac arrest (CA) causes ischemia-reperfusion injury in the whole body among victims. Especially in the brain, inflammation and neuronal cell death can lead to irreversible dysfunction. Our goal was to determine whether a single administration of soluble epoxide hydrolase inhibitor (AS2586144-CL) has a neuroprotective effect and decreases the inflammatory response after CA and cardiopulmonary resuscitation (CPR). Global cerebral ischemia was induced in male C57BL/6 mice with 8 min of CA. Thirty minutes after recovery of spontaneous circulation, the mice were randomly assigned to three groups and administered AS2586144-CL: 1 mg/kg (n = 25), 10 mg/kg (n = 25), or 0 mg/kg (vehicle, n = 25). At 6 and 7 days after CA/CPR, behavioral tests were conducted and brains were removed for histological evaluation. Analysis of histological damage 7 days after CA/CPR revealed that 10 mg/kg of AS2586144-CL protected neurons, and suppressed cytokine production and microglial migration into the hippocampus. Two hours after CA/CPR, 10 mg/kg of AS2586144-CL suppressed serum tumor necrosis factor-α and hippocampal nuclear factor κB expression. Our data show that 10 mg/kg of AS2586144-CL administered following CA/CPR suppresses inflammation and decreases neuronal damage." @default.
- W2359355557 created "2016-06-24" @default.
- W2359355557 creator A5022297857 @default.
- W2359355557 creator A5037397899 @default.
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- W2359355557 date "2016-10-01" @default.
- W2359355557 modified "2023-09-23" @default.
- W2359355557 title "Single administration of soluble epoxide hydrolase inhibitor suppresses neuroinflammation and improves neuronal damage after cardiac arrest in mice" @default.
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- W2359355557 doi "https://doi.org/10.1016/j.neures.2016.05.002" @default.
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