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- W2359364039 abstract "To valuate cross-protection between porcine circovirus(PCV) genetype 2a and 2b,four kinds of vaccines were prepared,respectively,including two virus inactivated vaccines of PCV2a-LG and PCV2b-YJ strains and their recombinant Cap subunit vaccines of PCV2a-rCap and PCV2b-rCap expressed by recombinant baculovirus.Eight-week-old BALB/c mice(n=165) were randomly divided into 11 groups(15 mice each).Each vaccine was immunized for 2 groups of mice and challenged with either homologous or heterologous genetype PCV2,with 2 challenge only and one blank control groups.No clinical signs were observed in all groups post challenge.However,the antibody titers were from 1∶200 to 1∶800 in all immunized groups at 5 weeks post immunization detected by IPMA.Of which the highest titers were found in PCV2a-rCap groups.The two inactivated vaccines and the PCV2a-rCap showed 100% protection against challenge with either PCV2a or PCV2b according to the virus load which was significantly reduced in the mice lung.Furthermore,the serum neutralization test demonstrated a high level cross-reactivity between the two genotype strains of PCV2.Histopathologic changes were developed in lung of control mice post challenge and no obvious changes were present in vaccinated mice.This study suggested that even though there were a certain degree of antigenic differences between two genotypes of PCV2 strains,the cross-immunization protection could be provided by both inactivated vaccines and PCV2a-rCap protein subunit vaccines." @default.
- W2359364039 created "2016-06-24" @default.
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- W2359364039 date "2012-01-01" @default.
- W2359364039 modified "2023-09-27" @default.
- W2359364039 title "Cross-protections between porcine circovirus genotype 2a and 2b with inactivated virus and recombinant Cap subunit vaccines" @default.
- W2359364039 hasPublicationYear "2012" @default.
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