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- W2359364904 abstract "Objective To study the prognostic significance of LRP, mdr 1,MRP gene expression in patients with acute leukemia.Methods Heparinized blood or bone marrow samples were obtained from 61 cases of acute leukemia and 15 normal controls. Monouclear cells were separated by the acid guanidium phenol chloroform method. The cDNA was synthesized using reverse transcriptase. The four pairs of primers chosen from the sequences of LRP, mdr 1,MRP and β 2 were used for the PCR. Results The positive percentrage of LRP. mdr 1 and MRP gene expression in relapsed refractory group were significantly higher than those in untreated, long term survival and normal control group ( P 0 05)。The 1st complete remisson (CR 1) rate of LRP mdr, MRP negative patients were obviously higher than positive ones in the untreated group. These multidrug resistance gene expressions were correlated with FAB classification. Conclusion High expression of LRP, mdr 1 and MRP gene is related to clinical multidrug resistance. Therefore, it may be regarded as an important factor of prognosis of patients with acute leukemia." @default.
- W2359364904 created "2016-06-24" @default.
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- W2359364904 date "2000-01-01" @default.
- W2359364904 modified "2023-09-24" @default.
- W2359364904 title "THE PROGNOSTIC SIGNIFICANCE OF LRP,MDR_1,MRP GENE EXPRESSION IN PATIENTS WITH ACUTE LEUKEMIA" @default.
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