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- W2359367223 abstract "Objective:To investigate the distribution of collagen type Ⅰ and Ⅱ in osteoarthritis cartilage.Mathods: Samples from two normal articular cartilage and seven osteoarthritis articular cartilage were collected.All the articular cartilages were stained with Safranin O and HE method. Extracellular deposition of collagen type Ⅰ and Ⅱ was analyzed immunohistochemically with monoclonal antibodies.Results:Immunohistochemistry revealed irregular and sometimes diminished inter territorial staining as well as enhanced pericellular deposits of collagen type Ⅱ.In some area pericellular loss of staining was also found.In superficial zone and middle zone,there were some irregular staining by collagen type Ⅰ monoclonal antibody,but no staining was found in normal cartilage.In fibro like area at the surface,the staining was markdely positive by collagen type Ⅰ,but no staining was shown by collagen type Ⅱ.Conclusion:Both synthesis and destroy of collagen type Ⅱ exist in osteoarthritis cartilage.In process of cartilage repair,the chondrocyte phenotype was modulated,and collagen type Ⅰ was expressed in cartilage." @default.
- W2359367223 created "2016-06-24" @default.
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- W2359367223 date "2002-01-01" @default.
- W2359367223 modified "2023-09-25" @default.
- W2359367223 title "Immunohistochemical Distribution of Type I and II Collagen in Osteoarthritis" @default.
- W2359367223 hasPublicationYear "2002" @default.
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