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- W2359369512 abstract "Objective To explore the characteristics and significance of axonal injury in cerebral white matter of hydrocephalic dogs. Methods 20 male dogs were divided into 4 groups according to the time of being killed (5 in each): 3 days group, 2 weeks group, 8 weeks group and control group. Hydrocephalus was induced by injecting kaolin into cisterna magna. Behavior and nervous function of dogs was assessed after operation. Neurofilament immunohistochemistry was performed to show the changes of axon in cerebral hemisphere white matter. At the same time, the ultrastructural changes of axonal cytoskeleton were also observed by electron microscope. Results Behavior of the dogs in test groups changed to different degree, but obvious functional impairment of nervous system only appeared 8 weeks after hydrocephalus induction; axonal damage occurred as early as 3 days after kaolin injection, and this phenomenon aggravated with the development of hydrocephalus; axonal injury was limited in periventricular white matter in 3 days and 2 weeks groups ,while spread to the area under cortex in 8 weeks group. Conclusion Axonal injury occurs in earlier period of hydrocephalus and persists to advanced stage. Its severity and circumscription has close relation with functional impairment of nervous system." @default.
- W2359369512 created "2016-06-24" @default.
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- W2359369512 date "2005-01-01" @default.
- W2359369512 modified "2023-09-23" @default.
- W2359369512 title "Neurofilament immunohistochemical study of axonal injury in cerebral white matter of hydrocephalic dogs" @default.
- W2359369512 hasPublicationYear "2005" @default.
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