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- W2359372406 abstract "To investigate the association between genetic variations in methylenetetrahydrofolate reductase (MTHFR) and the risk of colorectal cancer in a Chinese population.One hundred and ninety-eight cases of colorectal cancer and 420 controls were genotyped for detecting MTHFR C677T and A1298C polymorphisms by PCR-RFLP methods. The adjusted odds ratios (OR) and 95% confidence intervals (CI) were calculated by using unconditional logistic regression model.The frequency of the MTHFR C677T allele found among cases was significantly more frequent than that among controls (51.3% to 44.4%, P = 0.02). As compared with the 677CC genotype, the 677TT genotypes had a 67% (95% CI, 1.05 - 2.66) increased risk of colorectal cancers. However, there appeared no any correlations between the genetic variations of MTHFR and the cancer metastasis.These findings demonstrated that the genetic variation of MTHFR C677T should be a genetic susceptibility factor for colorectal cancer in a Chinese population." @default.
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- W2359372406 date "2005-11-01" @default.
- W2359372406 modified "2023-09-24" @default.
- W2359372406 title "[Association between genetic variations in methylenetetrahydrofolate reductase and risk of colorectal cancer in a Chinese population]." @default.
- W2359372406 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16329804" @default.
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