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- W2359383235 abstract "OBJECTIVE To investigate the effects of Wuling mycelia on seizure development and memory impairment induced by pentylenetetrazole-kindling epilepsy in rats.METHODS SD rats were randomly divided into four groups: pentylenetetrazole-kindling model group,low dose of Wuling mycelia(0.3 g·kg-1,ig) group,high dose of Wuling mycelia(0.6 g·kg-1,ig) group and control group.The rats were intraperitoneal injected with a subconvulsive dose(35 mg·kg-1) of pentylenetetrazole(saline in control group) every 48 h for 12 times.Wuling mycelia were intragastrically applied 30 min before every pentylenetetrazole injection.Memory was evaluated by shuttle box with passive avoidance and brain histamine was measured.RESULTS Wuling mycelia the kindling induced by pentylenetetrazole.The latency of passive avoidance of pentylenetetrazole-kindling model group was significantly shortened in shuttle box,which was reversed by Wuling mycelia.Brain histamine contents decreased after kindling induced by pentylenetetrazole,which were partially reversed by Wuling mycelia,especially in hippocampus and hypothalamus.CONCLUSION Wuling mycelia could postpone the kindling and ameliorate memory impairment induced by pentylenetetrazole kindling.The enhancement of neuronal histamine activity was one of possible mechanisms." @default.
- W2359383235 created "2016-06-24" @default.
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- W2359383235 date "2010-01-01" @default.
- W2359383235 modified "2023-09-28" @default.
- W2359383235 title "Effects of Wuling Mycelia on Seizure Development and Memory Impairment Induced by Pentylenetetrazole-Kindling Epilepsy in Rats" @default.
- W2359383235 hasPublicationYear "2010" @default.
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