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- W2359388613 abstract "AIM:To study the characteristics of sleep disturbances resulting from cocaine withdrawal.METHODS:Adult rats were instrumented with sleep-wake recording electrodes.Polygraphic signs of undisturbed sleep-wake activities were recorded for 24 h before cocaine administration,on withdrawal day 1(acute),day 8(subacute),and day 14(subchronic) during cocaine treatment.RESULTS:The sleep-wake cycles increased on withdrawal day 1(P0.05).Non-rapid eye movement(NREM) sleep increased during nighttime(P0.01) and daytime(P0.05) on withdrawal day 8.The increase in NREM sleep was significant during nighttime(P0.01) and slight during daytime on withdrawal day 14,whereas the rapid eye movement(REM) sleep was reduced during both daytime and nighttime(P0.01) on withdrawal day 8 and 14.In either daytime or nighttime period,no significant change was observed in the total sleep time during cocaine abstinence.During NREM and REM sleep as well as wakefulness,no difference was found in δ-,θ-and α-wave power density on withdrawal day 1,8 and 14.CONCLUSION:Sleep disturbance induced by acute,subacute,or subchronic cocaine withdrawal is predominantly due to abnormal alterations between NREM and REM sleep but not between sleep and wakefulness.The transition of sleep-wakefulness state is mostly disturbed during acute withdrawal,while sleep architecture dysfunction occurs during subacute or subchronic withdrawal." @default.
- W2359388613 created "2016-06-24" @default.
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- W2359388613 date "2011-01-01" @default.
- W2359388613 modified "2023-09-26" @default.
- W2359388613 title "Effects of cocaine withdrawal on sleep architecture and cortical electroencephalogram power spectra in rats" @default.
- W2359388613 hasPublicationYear "2011" @default.
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