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- W2359392242 abstract "Objective To observe the effects of different sedation regimes on immune function in patients undergoing mechanical ventilation.Methods Forty-nine patients undergoing mechanical ventilation were randomly divided into groups.Group A(23 cases) was given conventional continuous sedation with fentanyl and midazolam pumping.Sedation with fentanyl and midazolam pumping was adjusted to keep Ramsay scores of 2-4 points in group B(target sedation,26 cases).The patients in group B were awaked every day after midazolam infusion was replaced by propofol at 2 h before awake.The levels of HLA-DR,CD4/CD8,tumor necrosis factor(TNF) and interleukin(IL)-8 were measured before and on the 7th day after sedation.Results The expression of HLA-DR was significantly higher,the concentrations of IL-8 and TNF were lower in group B than those in group A after sedation.Conclusion Goal sedation can decrease the consumption of sedatives,reduce the immunosuppression." @default.
- W2359392242 created "2016-06-24" @default.
- W2359392242 creator A5081974901 @default.
- W2359392242 date "2010-01-01" @default.
- W2359392242 modified "2023-09-26" @default.
- W2359392242 title "Effects of sedation on immune function in patients undergoing mechanical ventilation" @default.
- W2359392242 hasPublicationYear "2010" @default.
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