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- W2359396435 abstract "Objective To examine the relationship of the K121Q variant of plasma cellmembrane glycoprotein-1(PC-1) gene with type 2 diabetes in old age population.Methods 228 type 2 diabetes subjects and 308 non-diabetes subjects without kinship were selected from the study data of type 2 diabetes in Beijing city community. All the subjects with type 2 diabetes had the family history of type 2 diabetes.All the subjects in this research were Han People. All subjects signed the informed consent before participation. For the case-control study,PCR-RFLP method was used to determine the distribution of allele and genotype frequencies of the K121Q variant in exon 4 of PC-1 gene.Results In 228 patients with type 2 diabetes,the KK,KQ,QQ genotypes were found in 177 cases (77.6%),46 cases(20.2%) and 5 cases(2.2%),the K,Q allele frequencies were 87.7% and 12.3%; In 308 healthy controls,the KK,KQ,QQ genotypes were found in 239 cases (77.6%),63 cases(20.5%) and 6 cases(1.9%),the K,Q allele frequencies were 87.8% and 12.2%; No significant difference was observed in the distribution of the genotype and allele in the two groups(P0.05). There was no gender difference of the distribution of the genotype and allele between type 2 diabetes subjects and control subjects(P0.05).The characteristics of BMI,WC and WHR were no significant difference among different genotypes(P0.05). Conclusion There was no obvious association between K121Q variant in PC-1 gene and type 2 diabetes in old age population." @default.
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- W2359396435 date "2008-01-01" @default.
- W2359396435 modified "2023-09-26" @default.
- W2359396435 title "Association Study of K121Q Variant in PC-1 Gene with Type 2 Diabetes in Old Age Population" @default.
- W2359396435 hasPublicationYear "2008" @default.
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