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- W2359397890 abstract "AIM To study the protective effects of dl-tetrahydrapalmatine (dl-THP) on focal brain ischemia-reperfusion injury in rats. METHODS Acute focal brain ischemia-reperfusion injury was produced by reversible middle artery occlusion without craniectomy in rats. dl-THP 5, 10, 20 mg· kg-1 was injected intravenously by 10 min before ischemia.RESULTS dl-THP dose-dependently decreased the size of cerebral infarction after ischemia for 2 h followed by reperfusion for 4 h. dl-THP also improved brain electrical activity, decreased the water content of injured brain, and reduced intracellular Ca2＋ accumulation resulted from ischemla-reperfusion event. CONCLUSION dl-THP had protective effects on acute focal brain ischemla-reperfusion injury. The drug might prevent the brain tissue from ischemia-reperfusion damage through reducing intracellular Ca2＋ accumulation resulted from ischemia-reperfusion event." @default.
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- W2359397890 date "1998-01-01" @default.
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- W2359397890 title "Protective effects of dl-tetrahydropalmatine on focal brain ischemia-reperfusion injury in rats" @default.
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