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- W2359417362 abstract "Objective:To study the mechanism of improvement in follicular development after using the Dane35 by detecting leukaemia inhibitory factor(LIF) and testosterone(T) in follicular fluid.Methods:19 patients with normal ovulation were taken as control group.40 patients with PCOS were taken as study group and divided into two subgroups,one subgroup was given the Dane35 three months.Follicular fluid were draw before and after treatment under B-scan in every women,LIF and T were detected in follicular fluid by ELISA and RIA.Statistic method was matched-pairs rank-sum test.Results:①Concentration of LIF and T before treatment:concentration of LIF in treatment group( 19.6±3.6 ng/L) was lower than control group(34.9±3.6 ng/L);concentration of T in treatment group(8.3±0.9μg/L) was higher than control group(5.0±1.1μg/L).There was no difference between treatment group and untreatment group (LIF was 19.4±3.2 ng/L,T was 8.2 ±1.0μg/L ).②Concentration of LIF and T after treatment:concentration of LIF in treatment group (27.9±6.0 ng/L) was higher than pretreatment(19.6±3.6 ng/L),but still lower than control group (35.3±3.7ng/L),concentration of T had no statistic change (8.3±0.9μg/L,7.2±1.3μg/L).There was no statistic change in concentration of LIF and T in untreatment group.③The relationship between follicular development and extent of raising in concentration of LIF T in:7cases of PCOS had well developed ovarian follicle,extent of rising in concentration of LIF in ripe follicle (16.3±3.2ng/L) was higher than unripe follicle (7.4±1.5ng/L),extent of descend in concentration of T in ripped follicle (1.4±0.16μg/L) was higher than unripe follicle (0.4±0.06μg/L).Conclusion:One of the reason that the Dane35 can improve follicle development is the Dane35 can change the concentration of LIF and T." @default.
- W2359417362 created "2016-06-24" @default.
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- W2359417362 date "2010-01-01" @default.
- W2359417362 modified "2023-09-23" @default.
- W2359417362 title "Change of LIF and T in follicular fluid after treatment by the Dane35 on patients with PCOS" @default.
- W2359417362 hasPublicationYear "2010" @default.
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