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- W2359431208 abstract "Objective To observe the expression of EGFR、p53 and morphological changes in submandibular gland of db/db mutant diabetic mice. Methods Fifty mice were divided into db/db diabetic group and control group randomly. The morphological changes of submandibular gland and the expression of EGFR、p53 were observed by light microscope (LM)and immunohistochemistry. Results In db/db diabetic mice, the results showed the submandibular gland atrophy and the significant morphological changes in acini and ducts . Immunohistochemistry results were as follow:、EGFR、p53 were expressed in submandibular gland from both diabetic mice and control mice. ②The percentage of immunopositive cells of EGFR、p53 was significantly more in diabetic mice than those of control mice, and there was continuous enhance of EGFR、p53 as disease progressed in diabetic groups. Conclusion db/db diabetes mellitus could induce submandibular gland atrophy and morphological changes of cells. The percentage of immunopositive cells of EGFR、p53 were increased with development of the disease, which could associate with the dysfunction of epithelial cells." @default.
- W2359431208 created "2016-06-24" @default.
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- W2359431208 date "2006-01-01" @default.
- W2359431208 modified "2023-09-25" @default.
- W2359431208 title "Expression of EGFR、p53 in snbmandibular gland of db/db mutant diabetic mice" @default.
- W2359431208 hasPublicationYear "2006" @default.
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