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- W2359432890 abstract "Objective To study the present situation of exposure to polycyclic aromatic hydrocarbons(PAHs),micronuclei frequency and the gene polymorphisms of CYP1A1,GSTM1 and GSTT1 of newborns,and further explore the relationship among the exposure,effects and the gene polymorphisms. Methods Field study were conducted in Taiyuan during the period of December 2006 to February 2007. 130 paired mother and newborn joined the study and umbilical cord blood were collected at delivery. Micronuclei frequency for each blood sample and five kinds of PAHs were determined in each serum sample. The gene polymorphisms of GSTM1,GSTT1 and CYP1A1 MspI were analyzed. The information of the mother and the development indexes of the newborns were collected by the questionnaires. The relationships among PAHs levels,micronuclei frequency and different gene polymorphisms were also analyzed to explore the effects of the gene polymorphisms on the prenatal PAHs exposure. Results 87.6% of the maternal urine samples showed higher 1-OH-Py levels compared with the common residents. Several kinds of carcinogenic PAHs were detected in serum of newborns. The micronuclei frequency of lymphocyte in umbilical cord blood of newborn was 1.26‰,still in the normal range. Pyrene levels in serum were higher among newborns with GSTM1 non-null genotype or CYP1A1 restrict site. The micronuclei frequency of lymphocyte in umbilical cord blood of newborn showed no significant differences among the different genotypes. Conclusion Mothers and newborns in Taiyuan selected in this study are highly exposed to PAHs. Gene polymorphism of GSTM1 GSTT1 and CYP1A1 may play little effects on micronuclei frequency. GSTM1 and CYP1A1 gene polymorphisms are involved in the metabolisms of pyrene." @default.
- W2359432890 created "2016-06-24" @default.
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- W2359432890 date "2008-01-01" @default.
- W2359432890 modified "2023-09-26" @default.
- W2359432890 title "Relationship between the Exposure Level of PAHs and the Gene Polymorphisms of CYP1A1,GSTM1 and GSTT1 among Newborns" @default.
- W2359432890 hasPublicationYear "2008" @default.
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