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- W2359451487 abstract "Objective To investigate the mechanism of airway neurogenic inflammation by studying the expression of inducible nitric oxide synthase(iNOS) and substance P(SP) induced by nerve growth factor(NGF)in PC12 cells and the modulatory effect of interferon regulatory factor 1(IRF-1).Methods PC12 cells were cultured,transfected with IRF-1-shRNA,and then stimulated with NGF.The expressions of SP mRNA and iNOS were determined by real-time PCR and Western blot,respectively.Results The expressions of SP mRNA and iNOS in PC12 cells were enhanced by stimulation with NGF(P0.5%).However,the expression of SP mRNA and iNOS in PC12 cells in which the expression of IRF-1 was blocked by IRF-1-shRNA decreased significantly(P0.5%).Conclusions NGF was involved in airway neurogenic inflammation by modulating the expression of SP mRNA and iNOS via IRF-1 in PC12 cells,and IRF-1 could be potentially a therapeutic target for airway neurogenic inflammation." @default.
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- W2359451487 date "2011-01-01" @default.
- W2359451487 modified "2023-09-28" @default.
- W2359451487 title "Nerve growth factor induced expression of inducible nitric oxide synthase and substance P in PC12 cell and the modulatory effect of interferon regulatory factor" @default.
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