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- W2359455846 abstract "【Objective】 To investigate the effect of FK409 on JAK2/STAT3 pathway during hepatic ischemia reperfusion injury after orthotopic liver transplantation in rats. 【Methods】Male Sprague-Dawley rats were used as donors and recipients in orthotopic liver transplantation (OLT) and were divided into FK409 group and Saline (NS) control group randomly according to whether FK409 was injected in vein 5 minutes before liver grafts harvesting. The third group was sham operation (SO). The animals were killed at 24 h after graft reperfusion or sham operation respectively. Paraffin-embedded specimen to detect rat liver apoptosis (TUNEL) and the protein expression of JAK2, STAT3 (immunohistochemical). Part of fresh liver tissue was collected to detect the expression of JAK2 mRNA and STAT3 mRNA by RT-PCR. 【Result】The apoptosis index (Al) of liver tissue and the expression of JAK2/STAT3 mRNA and protein of JAK2/STAT3 were lower in the group of FK409 than the group of NS significantly (P 0.05) at 24 hours after reperfusion. 【Conclusion】 FK409 may alleviates liver graft isehemia and reperfusion injury by JAK2/STAT3 pathway." @default.
- W2359455846 created "2016-06-24" @default.
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- W2359455846 date "2009-01-01" @default.
- W2359455846 modified "2023-09-25" @default.
- W2359455846 title "Efects of FK409 on JAK2/STAT3 pathway in rat liver transplantation after ischemia and reperfusion injury" @default.
- W2359455846 hasPublicationYear "2009" @default.
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