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- W2359455861 abstract "Objective: The pathogenic mechanism of premature ovarian failure (POF) remains unknown. Accumulated evidences indicate that abnormality in the immune system may be one of the major reasons and the imbalance of T helper type Ⅰ (Th1) and T helper type II (Th2) may play an important role in the process. Study of the distribution and functional state of Th1, Th2 may be helpful to elucidate the pathogenesis of POF. Methods: 13 patients with idiopathic POF and 7 women in reproductive age with normal cycle were enrolled in this study. The percentage of Th1 and Th2 cells from peripheral blood of patients and controls were studied using FITC labelled CD4 mAb to seperate CD4 + cell on FACs,in combination with in situ hybridization using Dig labelled IL2, IL6 cDNA probes. Results: Patients with POF had significantly higher percentage of Th1 cells as compared with the controls (49.76±9.22%, 20 06±7.10% respectively) ( P 0.001). The ratio of Th1/Th2 in patients with POF were significantly higher than that of controls (1.15±0.17, 0.63±0.09) ( P 0.001). Conclusions: The findings of this study suggest that patients with POF have increased Th1 cell activation, which may be related to the pathogenesis of POF." @default.
- W2359455861 created "2016-06-24" @default.
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- W2359455861 date "1998-01-01" @default.
- W2359455861 modified "2023-09-24" @default.
- W2359455861 title "Distribution of CD4 + lymphocyte Th1/Th2 subsets in peripheral blood of women with idiopathic premature ovarian failure" @default.
- W2359455861 hasPublicationYear "1998" @default.
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