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- W2359456320 abstract "Objective:To compare the change of weight,glycometabolism and lipoprotein in schizophrenia that were treated with Chlorpromazine or Risperidone for 12 months,in order to establish an intervention model to reduce the risk of obesity,abnormal glycometabolism and lipoidosis.Methods:All consecutive patients with first episode schizophrenia at our referral psychiatric hospital were recruited in a prospective nonrandomized study including measures of weight,height,fasting plasma glucose(FPG),2 hour of sugar tolerance test(2HPG) and postprandial blood sugar(2HPBG),glycosylated hemoglobin(HbA1c),total cholesterol(TC),triglyceride(TG),high-density lipoproteins(HDL),and low density lipoprotein(LDL) levels both at admission and the endpoint of 3、6、12 months later,and to receive either,Chlorpromazine or Risperidone according to the odd or even number.Results: Altogether there were 198 patients participated in the study.And there were no significant differences between the Chlorpromazine-and the Risperidone-treated group at the admission.After3、6 and 12 months,there were significant differences of the concentration of FPG、2HPBG、2HPG、HbA1C、TC、TG、HDL、LDL and the weight between two treatment groups,and among the three groups classified by the increase of weight(≤0、0~5%、≥5%).The results of logistic regression were that,the risk factors of abnormal glycometabolism were age and antipsychotics,and the lipoidosis was the elevated TG at the admission.Conclusions: Chlorpromazine has more effects than Risperidone on the weight,the concentration of serum glucose and lipoprotein in schizophrenia.And there need further study to identify the relationship between the obesity and lipoidosis and diabetic mellitus induced by antipsychotics." @default.
- W2359456320 created "2016-06-24" @default.
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- W2359456320 date "2010-01-01" @default.
- W2359456320 modified "2023-09-28" @default.
- W2359456320 title "The one year follow-up of weight and metabolism of serum glucose and lipoprotein in schizophrenia with Chlorpromazine or Risperidone" @default.
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