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- W2359458242 abstract "OBJECTIVE To prepare hydroxycamptothecinsemisolid lipid nanoparticles(HCPT-SSLN) and study the release profile in vitro.METHODS HCPT-SSLN was prepared by the method of emulsion evaporation and solidification at a low temperature;the particle size and ξ potential were determined by laser granularity equipment;the physical stability of both suspension and lyophiled powder of HCPT-SSLN were investigated;dialyzer was used to study the release of HCPT in vitro.RESULTS The mean particle size of the prepared HCPT-SSLN was 130.5 nm,drug loading(DL) was 2.51%,entrapment efficiency(EE) was 79.19%,ξ potential was-33.1 mV;Placed at room temperature and 4 ℃ for 6 months,the appearance,particle size and entrapment efficiency of HCPT-SSLN were all stable;The release rule in vitro was subject to Weibull equation:lnln[1/(1-Q)]=0.263 3lnt+0.050 9(R2=0.948 5).CONCLUSION The HCPT-SSLN has high entrapment efficiency,good stability,uniform particle size,and can retard drug release in vitro." @default.
- W2359458242 created "2016-06-24" @default.
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- W2359458242 date "2007-01-01" @default.
- W2359458242 modified "2023-09-23" @default.
- W2359458242 title "Preparation and in vitro drug-release behavior of hydroxycamptothecin semisolid lipid nanoparticles" @default.
- W2359458242 hasPublicationYear "2007" @default.
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