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- W2359466096 abstract "Objective To investigate the inhibitive effects of andrographolide on lipopolysaccharide-induced inflammation factors secretion in macrophage cells.Methods A macrophage cell line RAW264.7 cells were cultured in vitro,and treated with different concentration of andrpgrapholide in the presence or absence of lipopolysaccharide (LPS). The production of inflammatory factor nitric oxide (NO),tumor necrosis factor-α(TNF-α) and interleukin-6 (IL-6) in the supernatant was measured by Griess reagent and Elisa,respectively.Results After stimulated with LPS,the content of NO,TNF-α and IL-6 were markedly up-regulated. Pretreated with andrographolide significantly inhibited LPS-induced inflammation factors expression levels,which was statistically significant compared with LPS group(P0.05).Conclusion These results indicated that andrographolide might effectively blocks inflammation by down-regulating production of NO,TNF-α and IL-6." @default.
- W2359466096 created "2016-06-24" @default.
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- W2359466096 date "2010-01-01" @default.
- W2359466096 modified "2023-09-24" @default.
- W2359466096 title "Andrographolide inhibits LPS-induced inflammation factors expression in macrophage cells" @default.
- W2359466096 hasPublicationYear "2010" @default.
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