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- W2359469093 abstract "【Objective】 To study the preventive effect of licorice flavonoids (LF) on hyperglycemia and hyperlipemia of experimental diabetic rats induced by feeding high-fat and high-sugar diet combined with low-dose streptozotocin (STZ) injection,and to elucidate its possible pharmacological mechanisms.【Methods】The rats were divided into four groups,namely as control group,control treatment group (CLF),model group and preventive treatment group (PLF). Rats in control group and CLF group were fed with normal diet,while rats in the other two groups were fed with high-fat and high-sugar diet. Meanwhile,rats in CLF and PLF groups were administered with 300 mg(/kg body.d)of LF. Rats in control and model groups were administered with solvent (1.2-propanediol). 6w later,the model group and PLF group were injected STZ (35 mg/Kg). 6d later,the body weight,levels of the fasting blood glucose (FBG),triglycerides (TG),total cholesterol (TC),high-density lipoprotein cholesterol (HDL-C),low-density lipoprotein cholesterol (LDL-C) and total antioxidation capability (T-AOC) of all experimental animals were examined. Liver,kidney,fat around kidney,epididymis and epiploon were weighed. Liver index,kidney index and the relative weight of abdominal adipose tissue were calculated. 【Results】LF preventive treatment significantly inhibited the increase in levels of FBG,TG,TC,LDL-C and liver index,it also significantly increased the levels of T-AOC and inhibited the decrease in body weight and relative weight of abdominal adipose tissue.【Conclusion】 LF is effective in preventing occurrence of experimental diabetes in rats." @default.
- W2359469093 created "2016-06-24" @default.
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- W2359469093 date "2010-01-01" @default.
- W2359469093 modified "2023-09-25" @default.
- W2359469093 title "Preventive effect of licorice flavonoids on experimental diabetes in rats" @default.
- W2359469093 hasPublicationYear "2010" @default.
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