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- W2359506006 abstract "Objective To evaluate the cerebral protection mechanism of ganglioside sodium on patients with acute severe brain injury. Methods Forty-seven patients with acute severe brain injury from intensive care unit of the central hospital of Zhumadian city were divided into control group(22 cases) and observation group(25 cases) according to the treatment methods,all patients were given treatment of dehydration,hemostatic,antiphlogistic,trophic nerve,mild hypothermia brain protection or neurosurgical operation. Patients in observation group were given intravenous drip of 100 mg ganglioside sodium plus250 mL isotonic saline solution besides the above treatment,once a day,the dose decreased to 40 mg after 14 days,treatment course was three weeks. The levels of tumor necrosis factor α(TNF-α),endothelin 1(ET-1),neuropeptide Y(NPY) and calcitonin gene related peptide(CGRP) in blood before treatment and 3,7,14 and 21 days after treatment in the two groups were detected and analyzed,and all the patients were given telephone and outpatient follow-up for three months,and the prognosis of the two groups were compared. Results The TNF-α,ET-1 and NPY levels in blood of all the patients at 3,7,14 and 21 days after treatment were lower than those before treatment,while the CGRP level after treatment was higher than that before treatment significantly(P 0. 05). The TNF-α,ET-1 and NPY levels of patients in observation group at 3,7,14 and 21 days after treatment were lower than those of control group,while the CGRP level of observation group after treatment was higher than that of control group significantly(P 0. 05). The cure rate of observation group was higher than that of control group significantly(P 0.05). Conclusion Lowering the intracranial pressure,surgical operation and other traditional treatment combine with ganglioside sodium can produce clear protective effect of the brain,and can improve the prognosis of the patients with acute severe brain injury." @default.
- W2359506006 created "2016-06-24" @default.
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- W2359506006 date "2014-01-01" @default.
- W2359506006 modified "2023-09-26" @default.
- W2359506006 title "Cerebral protection mechanism of ganglioside sodium on patients with acute severe brain injury" @default.
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