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- W2359506990 abstract "Objective:To investigate the effect of continuous positive airway pressure(CPAP)on serum NO and plasma ET and myocardial structure in mini pigs with obstructive sleep apnea syndrome(OSAS).Methods:Twenty-four male mini pigs were evenly randomized into 4 groups:normal control group(group A),OSAS model group(group B),CPAP treated group(group C)and positive control group(group D).Animals in group A were not treated and those in the other 3 groups were treated with intermittent hypobaric hypoxia 6 h daily for 22 d.Animals in groups C was also given further CPAP treatment 6 h daily for 30 d.The animals in group D were raised for 30 d and were sacrificed together with those in group C;the animals in group A and group B were sacrificed simultaneously.Sleep monitoring and determination of serum NO and plasma ET were performed before execution and pathological examination of myocardial structure after execution.Results:The apnea-hypopnea index(AHI)of group C was significantly lower than those of group B and D and higher than that of group A(P0.05);the SpO2 of group C was significantly higher than those of group B and D(P0.05),and was similar to that of group A.The levels of NO in group A,B,C,and D were(0.221±0.062),(0.115±0.061),(0.110±0.033),(0.077±0.043)μmol/L,respectively,and the levels of ET were(40.2±4.8),(99.8±22.4),(67.1±18.5),and(103.7±30.1)pg/ml,respectively.Group C had significantly higher NO level and lower ET level compared with group D(P0.05).The ET level in group C was significantly lower than that in group B(P0.05).Pathological examination showed that the myocardial structure in group B,C,and D all had hypoxia and ischemia damage compared with group A;the damage in group C was slighter than that in group B and D,but severer than that in group A.Conclusion:Thirty day-treatment with CPAP can improve the sleeping indices,plasma ET and serum NO level,and myocardial structure of OSAS mini pigs." @default.
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- W2359506990 date "2009-01-01" @default.
- W2359506990 modified "2023-09-25" @default.
- W2359506990 title "Effect of continuous positive airway pressure on myocardial structure and plasma NO and ET in mini pigs with obstructive sleep apnea syndrome" @default.
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