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- W2359515257 abstract "Objective To study the influence of Dendrobium Compound (DC) on mRNA and protein expression of Bax, Bcl-2 genes associated with apoptosis in aged diabetic rats’ pancreas, and to investigate its possible functionary mechanism.Methods The aged diabetic rats model was induced by D-galactose, enrich-diet and Streptozotocin (STZ low dose) to measure the concentration of SOD and MDA in serum, and detect mRNA and protein expressions of Bax and Bcl-2 genes by RT-PCR and Western-Blot.Results MDA concentration in each DC treat group evidently declined (P0.05), but SOD markedly ascended(P0.05～0.01)compared to those of the aged and aged diabetes group. Bax mRNA and protein expression evidently declined(P0.05～0.01)but Bcl-2mRNA increased markedly(P0.05)in treatment group.Conclusions 1. Bax/Bcl-2 in aged rats markedly ascended, and that in aged diabetic rats was higher. There was an unbalance between the mRNA and protein expression of Bax and Bcl-2, especially in aged diabetic rats. 2. DC could decrease the blood glucose and MDA, evidently raise SOD of the aged rats and the aged diabetic rats. One of its molecular mechanisms might be associated with decreasing the expression level of Bax and increasing that of Bcl-2, which regulate the unbalance between mRNA and protein expression of Bax and Bcl-2." @default.
- W2359515257 created "2016-06-24" @default.
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- W2359515257 date "2006-01-01" @default.
- W2359515257 modified "2023-09-25" @default.
- W2359515257 title "The regulation of Dendrobium Compound (DC) on mRNA and protein expression of Bax, Bcl-2 genes associated with apoptosis in aged diabetic rats’ pancreas" @default.
- W2359515257 hasPublicationYear "2006" @default.
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