Matches in SemOpenAlex for { <https://semopenalex.org/work/W2359523471> ?p ?o ?g. }
Showing items 1 to 69 of
69
with 100 items per page.
- W2359523471 abstract "【Objective】To study the effects of rhein derivative RH-01 on the osteosarcoma(HOS)cells.【Methods】HOS cells were treated with RH-01 at different concentrations.The growth inhibition of HOS cells was analyzed by MTT assay.The effect of RH-01 on tumor growth was studied by kunming mice transplanted models with entity-type S180 carneus.Hydroxyapatite ceramic absorption assay and ultraviolet spectrophotometry was employed to analyzed the bone-affinity effect of RH-01 in vitro and vivo respectively.【Results】RH-01 remarkably inhibiteds the growth of HOS cells,the IC50 value was 0.18 μmol/L.After ten days of administering RH-0 130 mg·(kg·d)-1and 60 mg·(kg·d)-1,the S180 carneus in average group was dramatically lighter than the one in negative control group,with inhibition rate of 64.54% and 77.26% respectively.The result of hydroxyapatite ceramic absorbing assay showed that its values towards ACM and RH-01 were 8.1 umol/g and 14.8 μmol/g respectively.And that the RH-01's spectrogram in bone surveyed by ultraviolet spectrophotometry was the same as Podophyllotoxin,it showed that at the wavelengths of 254 nm,the contents of RH-01 inside bone turned out to be(5.39±0.03)μg/mg after 12 hours,while the contents of Podophyllotoxin being(3.29±0.03)μg/mg.【Conclusions】The compound RH-01 could obviously inhibit the growth of HOS cell line in vitro and S180 carneus in vivo.It also has a very strong bone-affinity feature in vitro and vivo." @default.
- W2359523471 created "2016-06-24" @default.
- W2359523471 creator A5083980357 @default.
- W2359523471 date "2008-01-01" @default.
- W2359523471 modified "2023-09-26" @default.
- W2359523471 title "Effect of rhein derivative RH-01 on the growth of osteosarcoma" @default.
- W2359523471 hasPublicationYear "2008" @default.
- W2359523471 type Work @default.
- W2359523471 sameAs 2359523471 @default.
- W2359523471 citedByCount "0" @default.
- W2359523471 crossrefType "journal-article" @default.
- W2359523471 hasAuthorship W2359523471A5083980357 @default.
- W2359523471 hasConcept C13965031 @default.
- W2359523471 hasConcept C142724271 @default.
- W2359523471 hasConcept C150903083 @default.
- W2359523471 hasConcept C153911025 @default.
- W2359523471 hasConcept C16685009 @default.
- W2359523471 hasConcept C185592680 @default.
- W2359523471 hasConcept C202751555 @default.
- W2359523471 hasConcept C207001950 @default.
- W2359523471 hasConcept C2777760704 @default.
- W2359523471 hasConcept C2778143360 @default.
- W2359523471 hasConcept C2780783641 @default.
- W2359523471 hasConcept C55493867 @default.
- W2359523471 hasConcept C71240020 @default.
- W2359523471 hasConcept C71924100 @default.
- W2359523471 hasConcept C86803240 @default.
- W2359523471 hasConceptScore W2359523471C13965031 @default.
- W2359523471 hasConceptScore W2359523471C142724271 @default.
- W2359523471 hasConceptScore W2359523471C150903083 @default.
- W2359523471 hasConceptScore W2359523471C153911025 @default.
- W2359523471 hasConceptScore W2359523471C16685009 @default.
- W2359523471 hasConceptScore W2359523471C185592680 @default.
- W2359523471 hasConceptScore W2359523471C202751555 @default.
- W2359523471 hasConceptScore W2359523471C207001950 @default.
- W2359523471 hasConceptScore W2359523471C2777760704 @default.
- W2359523471 hasConceptScore W2359523471C2778143360 @default.
- W2359523471 hasConceptScore W2359523471C2780783641 @default.
- W2359523471 hasConceptScore W2359523471C55493867 @default.
- W2359523471 hasConceptScore W2359523471C71240020 @default.
- W2359523471 hasConceptScore W2359523471C71924100 @default.
- W2359523471 hasConceptScore W2359523471C86803240 @default.
- W2359523471 hasLocation W23595234711 @default.
- W2359523471 hasOpenAccess W2359523471 @default.
- W2359523471 hasPrimaryLocation W23595234711 @default.
- W2359523471 hasRelatedWork W1540824853 @default.
- W2359523471 hasRelatedWork W229406300 @default.
- W2359523471 hasRelatedWork W2322309662 @default.
- W2359523471 hasRelatedWork W2347671581 @default.
- W2359523471 hasRelatedWork W2349686623 @default.
- W2359523471 hasRelatedWork W2350981046 @default.
- W2359523471 hasRelatedWork W2363014831 @default.
- W2359523471 hasRelatedWork W2364133014 @default.
- W2359523471 hasRelatedWork W2366582702 @default.
- W2359523471 hasRelatedWork W2366909228 @default.
- W2359523471 hasRelatedWork W2367544369 @default.
- W2359523471 hasRelatedWork W2379264214 @default.
- W2359523471 hasRelatedWork W2379303858 @default.
- W2359523471 hasRelatedWork W2379577691 @default.
- W2359523471 hasRelatedWork W2381423497 @default.
- W2359523471 hasRelatedWork W2382584680 @default.
- W2359523471 hasRelatedWork W2391700646 @default.
- W2359523471 hasRelatedWork W2392366295 @default.
- W2359523471 hasRelatedWork W2400511492 @default.
- W2359523471 hasRelatedWork W3032522535 @default.
- W2359523471 isParatext "false" @default.
- W2359523471 isRetracted "false" @default.
- W2359523471 magId "2359523471" @default.
- W2359523471 workType "article" @default.