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- W2359526083 abstract "Objective To develop a noninvasive method for delivering IGF-Ⅰ to the brain bypassing the blood-brain barrier (BBB) to be a major challenge to the treatment of brain injury. Methods IGF-Ⅰ was radiolabeled with 125 I (50 μg IGF-Ⅰ, 25 μCi ) in order to perform the qualitative distribution and autoradiography of IGF-Ⅰ in brain areas, spinal cord, cerebrospinal fluid, blood and peripheral organs following intranasal (IN) versus intravenous (IV) administration after middle cerebral artery was occluded (MCAO) in rats. Infarction volumes after treatment with IN IGF-Ⅰ were also evaluated 24 h following the onset of MCAO. Results Autoradiography and quantitative measurement of radiolabeled IGF-Ⅰ demonstrated a much (8-166 times) higher delivery of IN than IV IGF-Ⅰ to the brain regions, cervical spinal cord and cerebrospinal fluid (CSF) (P0.01). The highest region is olfactory bulb, followed by CSF and hypothalamus. In addition, treatment with the IN 50 μg IGF-Ⅰ might significantly reduce the infarction volume by 62 vs control (P=0.01). However, treatment with IV 50 μg IGF-Ⅰ was ineffective to reduce infarction volume. Conclusion IGF-Ⅰ might be delivered to the brain directly from the nasal cavity following IN administration, bypassing the BBB. This noninvasive, a simple and cost-effective method should be a potential treatment for the stroke." @default.
- W2359526083 created "2016-06-24" @default.
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- W2359526083 date "2004-01-01" @default.
- W2359526083 modified "2023-09-25" @default.
- W2359526083 title "Intranasal delivery of insulin-like growth factor-I to central nervous system via the olfactory pathway and its resulting in protection against cerebral infarct in rats" @default.
- W2359526083 hasPublicationYear "2004" @default.
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