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- W2359532795 abstract "Objective To investigate the effects of tramadol pretreatment on the expression of substance P(SP) in ischemia and non-ischemia myocardium following the acute myocardial ischemia.Methods Eighteen adult male Sprague-Dawley rats weighing 270-300 g were randomly divided into 3 groups(n=6 in each group):sham group,ischemia group and tramadol group.The left anterior descending branch of coronary artery was occluded for 3 h in ischemia group and tramadol group.In tramadol group,tramadol 12.5 mg/kg was additionally injected through caudal vein 15 min before coronary artery occlusion(CAO).The hearts were removed at the end of 3 h for determining the SP protein expression by immunohistochemistry and enzyme immunometric assay and the expression of SP mRNA by RT-PCR in ischemia and non-ischemia myocardium.Results Compared with sham group,SP and SP mRNA levels were increased significantly in ischemia group and tramadol group in myocardium of ischemic and non-ischemic areas(P0.05),but the levels were significantly higher in ischemia group than those in tramadol group(P0.05).Conclusion Tramadol pretreatment can significantly inhibit the SP expression in myocardium evoked by CAO,which suggests that tramadol pretreatment might take part in the cardioprotection against acute myocardial ischemia." @default.
- W2359532795 created "2016-06-24" @default.
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- W2359532795 date "2012-01-01" @default.
- W2359532795 modified "2023-09-23" @default.
- W2359532795 title "Effects of tramadol pretreatment on expression of substance P in myocardium after acute myocardial ischemia in rats" @default.
- W2359532795 hasPublicationYear "2012" @default.
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