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- W2359533829 abstract "To investigate the influence of pyruvate on HMGB-1 concentration and survival of sepsis rats.The rats were executed cecal ligation and puncture for experimental sepsis which randomly divided into 5 groups(fake operation,blankcontrol,physiological saline,positive control and pyruvate).The inflammation factors,such as TNF-α,IL-6 and HMGB-1 concentration were tested by ELISA.We compared the rates of different groups by Kaplan-Meier method.Then,we assess pyruvate these inflammation factors concentration in different group.To assess the survival effects on experimental septicemia rats at different dose-rates and in different administration time.After cecal ligation and puncture,TNF-αand IL-6 concentration of all groups obviously increased at once,after two days the concentration to reach the peak,and then began to decline.We compared the uptrend,blank control and physiological saline group was obviously higher than other three groups(P0.05).The HMGB-1 concentration of all groups obviously increased after cecal ligation and puncture two days,the concentration to reach the peak after 5 days,and then began to decline.We compared the uptrend,fake operation and pyruvate group obviously slower than other three groups(P0.05).The best concentration and administration time of pyruvate to experimental sepsis rats was 4mg per kilogram of body weight and 24 hours after executed cecal ligation and puncture respectively.Compared the other four groups,pyruvate significant decreased the HMGB-1 concentration of experimental sepsis rats.Compared the survival rate,the pyruvate group was obviously higher than and blank control and physiological saline group(P0.05).Pyruvate can significant decreased the HMGB-1 concentration of experimental septicemia rats,also can improve the survival rate of experimental sepsis rats.Pyruvate has a certain therapeutic action for experimental septicemia rats." @default.
- W2359533829 created "2016-06-24" @default.
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- W2359533829 date "2011-01-01" @default.
- W2359533829 modified "2023-09-23" @default.
- W2359533829 title "The Influence of Pyruvate on the Survival Rate of Experimental Septicemia Rats" @default.
- W2359533829 hasPublicationYear "2011" @default.
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