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- W2359534676 abstract "Objective To investigate the role of Chinese herbs, Astragali and Angelica(AA) in acute renal ischemia/reperfusion injury, and the related intracellular signal transduction mechanism. Methods Acute ischemic renal injury in rats was made by placing the atraumatic vascular clamp in renal pedical for 45 minutes. Rats in AA group were given a sigle dose(2 ml/d) of AA decoction by gastric gavage for 3 days before ischemia, and then continued to the 3th day after ischemia/reperfusion. Serum creatinine(Scr) and renal pathological changes were compared between AA and control group. The PCNA positive cells in renal tissue were detected by immunohistochemistry. ERK and JNK activity was assayed by specific substrate phosphorylation with immunoprecipitation. Results At 24 hours of reperfusion, Scr value was lower in AA group than that in the control. Much less necrotic tubular cells, casts, and more PCNA-positive cells were found in AA group compared to the control. ELK activity decreased at 45 min of ischemia, and recovered at 5 min of reperfusion. There was no difference between two groups. JNK activity did not change after ischemia, but increased at 5 min and peaded at 20 min of reperfusion. It was significantly higher in AA group than that in the control group. Conclusion Chinese herbs AA protect kidney against ischemic insult and accelerate the recovery after acute renal ischemia/reperfusion injury, which may associate with the change of JNK signaling pathway." @default.
- W2359534676 created "2016-06-24" @default.
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- W2359534676 date "2000-01-01" @default.
- W2359534676 modified "2023-09-22" @default.
- W2359534676 title "The protective and accelerating recovery role of Astragali and Angelica on renal ischemia/ reperfusion injury" @default.
- W2359534676 hasPublicationYear "2000" @default.
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