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- W2359552012 abstract "Objective To investigate the hepatic expression of genes involving in the metabolism of cholesterol and bile acids which lead to cholesterol supersaturation of the bile in Chinese patients with gallstones. Methods Twenty-two non-obese normolipidemic patients (female/male 11/11) with gallstones (GS) from Shanghai,China,were investigated together with 13 gallstone-free controls (matched by age and body mass index; female/male 10/3). Liver biopsies,gallbladder bile and serum samples were collected. Gene expression was performed by real-time PCR,bile acids and cholesterol metabolites by mass spectrometry,and proteins by Western blotting. Results The bile from the gallstone patients had higher cholesterol saturation than the controls. The mRNA levels of ABCG5/ABCG8,and LXRα in the GS patients were increased by 51%,59% and 102% respectively,and the mRNA levels correlated well with both the molar % of biliary cholesterol and cholesterol saturation index. The mRNA and protein levels of the hepatic scavenger receptor B type I(SRBI) both were increased,and a significant correlation was found between the protein levels and the cholesterol saturation index. No differences were noted between the two groups concerning the hepatic synthesis of cholesterol and bile acids,and esterification of cholesterol. Conclusions The upregulation of ABCG5/ABCG8 in the GS patients,possibly mediated by increased LXRα expression,may account for the cholesterol supersaturation of the bile. The increased amounts of biliary cholesterol may orginate from plasma high-density lipoprotein(HDL) cholesterol by enhanced transfer via the SRBI,rather than emanating from de novo cholesterol synthesis or decreased esterification." @default.
- W2359552012 created "2016-06-24" @default.
- W2359552012 creator A5058490930 @default.
- W2359552012 date "2007-01-01" @default.
- W2359552012 modified "2023-09-25" @default.
- W2359552012 title "Identification of the molecular defects in the liver underlying gallstone disease in non-obese Chinese patients" @default.
- W2359552012 hasPublicationYear "2007" @default.
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