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- W2359574606 abstract "Acetylcholinesterase (AChE) is a type of hydrolytical enzyme mainly found in the nervous system. The most important function of AChE is to terminate neuron impulses at cholinergic synapses by hydrolyzing the neurotransmitter acetylcholine (ACh). In recent years, the complexity of AChE gene regulation and newly found evidence reveal that AChE has some non-classical functions, which have driven a profound exploration into acetylcholinesterase research. Non-classical functions of acetylcholinesterase include the differentiation, migration and formation of synapses in nerve cells, proliferation and differentiation in hematopoiesis, as well as growth regulation in tumorigenesis. Recently, expression of AChE was observed in several apoptotic cell lines and primary cultured cells. AChE was highly expressed in the neuroblastoma, SK-N-SH cell line, which implied that neuron and glial cell could overexpress AChE during apoptosis. It has been shown that AChE plays important role during apoptosis of AD." @default.
- W2359574606 created "2016-06-24" @default.
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- W2359574606 date "2002-01-01" @default.
- W2359574606 modified "2023-09-25" @default.
- W2359574606 title "Non-classical function of acetylcholinesterase and its relation with Alzheimer's disease" @default.
- W2359574606 hasPublicationYear "2002" @default.
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