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- W2359575052 abstract "Objective:To investigate the effects of remifentanil and propofol on spatial learning and memory and the expression of choline acetyltransferase(ChAT) in the hippocampus of aged rats.Methods:Fifty male SD rats aged 18 months were randomly divided into 5 groups(n=10): control 1-week group(group N1),propofol 1-week group (group P1),remifentanil 1-week group(group R1),control 3-week group(group N3) and propofol 3-week group(group P3).The rats in group R1 received intravenous remifentanil 60 μg/kg,followed by remifentanil 15 μg /(kg·min) for 1 h.The rats in group P1 and P3 received intraperitoneal propofol 60 mg/kg and supplemental propofol 30 mg/kg when the rats appeared to righting reflex for 2 times,whereas the rats in control group were given equal volume normal saline in the way described above.The rats were tested with Morris water maze 4 times a day for 4 consecutive days in the 1st week or 3rd week after drug administration.The rats were infused 4% paraformaldehyde after tests and then the brain was removed for determination of hippocampal structure and ChAT expression using HE and immuno-histochemical staining.Results:① Morris water maze test showed that only the latency of group P1 was significantly longer than group N1 compared with anaesthetized and control groups(P0.01 or P0.05).There was no significant difference in the number of across the original platform between anaesthetized group and control group in the spatial probe test.②HE staining exposed no histological lesions of hippocampus in all groups.③Immunohistochemical staining suggested that there was no significant differences of ChAT expression in CA1 region of hippocampus between anesthetized groups and control groups.Conclusion:The data indicate anesthesia-dose propofol can lead to temporary spatial learning and memory impairment in aged rats but remifentanil infusion does not produce such effect.Remifentanil and propofol have no effects on ChAT expression in hippocampus of aged rats 4 days and 3 weeks after anesthesia." @default.
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- W2359575052 date "2008-01-01" @default.
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- W2359575052 title "Effects of remifentanil and propofol on spatial learning and memory in aged rats" @default.
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