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- W2359575962 abstract "AIM:To assess the analgesic efficacy and safety of lornoxicam on patient-controlled analgesia (PCA) undergoing hysterectomy and influence of lornoxicam on beta-endorphin serum concentration. METHODS: Sixty patients scheduled for abdominal hysterectomy under general anaesthesia were randomly divided into lornoxicam group and morphine group. According to the necessity, two drugs administered iv via a patient-controlled analgesia for up to 24 h,postoperatively(lornoxicam group,bolus=0.8 mg lornoxicam ,lock-out time 5 min. monphine group, bolus=(1 mg) morphine, lock-out time 5 min).Efficacy was assessed by comparing hourly pain relief(PAR),total pain relief (TOTPAR)and patient's evaluation of the efficacy of PCA received. Adverse reactions like vomiting, respiratory depression and abdominal distension were also observed. Platelet aggregation with functions of kidney and liver were monitored. Beta-endorphin and cortisol concentrations were measured before and after the operation. RESULTS: There were no statistically significant difference between the two groups in TOTPAR and patient's general evaluation of the efficacy (P 0.05). Lornoxicam caused fewer adverse reactions such as vomiting than morphine (P0.01). Statistical analysis also revealed no significant difference in platelet aggregation (P 0.05). Concentrations of beta-endorphin increased significantly in both groups 3 h after PCA start (P0.01), and there were no statistically significant difference between the two groups (P 0.05). CONCLUSION: Lornoxicam offers an useful alternative to morphine for the PCA with less adverse reactions. Lornoxicam can induce the notable increase of beta-endorphin under stress which needs further study." @default.
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- W2359575962 date "2005-01-01" @default.
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- W2359575962 title "Analgesia effects of lornoxicam on postoperative total hysterectomy pain and influence on beta-endorphin serum concentration" @default.
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