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- W2359585622 abstract "Objective To investigate the effects of etomidate infusion with different duration on adrenocortical function.Methods Sixty general anesthesia patients (ASA Ⅰ or Ⅱ) underwent selective operation were randomly divided into 6 groups, etomidate group: E1,E2 and E4 group(continuous infusion etomidate 1 h,2 h and 4 h),and propofol group: P1,P2 and P4 group (continuous infusion propofol 1 h,2 h and 4 h), 10 case each group.Anesthesia was maintained with infusion of etomidate 8-10 μg·kg-1·min-1 in group E, propofol 4-6 mg·kg-1·h-1 in group P. Blood samples for the measurement of cortisol, aldosterone and adrenocorticotrophic hormone (ACTH) were collected before induction 5 min (T0) and 1 h (T1), 2 h (T2), 4 h (T3), 6 h (T4), 24 h (T5) after induction.Results Compared with T0, the plasma levers of cortisol decreased at T1 and T2 in group E1 (P0.05), decreased at T1-T3 in group E2 and E4 (P0.05), no significant change in group P. Aldosterone decreased at T1 and T2 in group E1 (P0.05), decreased at T2 and T3 in group E2 and T1-T4 in group E4 (P0.05), decreased at T1 in group P2 and P4(P0.05). ACTH increased at T2 in group E2 (P0.05), increased at T2 and T3 in group E4 (P0.05). All levels were normal, eighty percent of cortisol, all aldosterone and ACTH values could restore to preoperative level at T5. There were no adrenal insufficiency occurred in our study.Conclusion The inhibition of etomidate on the function of adrenocortical is temporal and safe for continuous infusion 4 h of those who are not hypoadrenocorticism." @default.
- W2359585622 created "2016-06-24" @default.
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- W2359585622 date "2012-01-01" @default.
- W2359585622 modified "2023-09-23" @default.
- W2359585622 title "Effects of etomidate infusion with different duration on adrenocortical function" @default.
- W2359585622 hasPublicationYear "2012" @default.
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