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- W2359594492 abstract "Objective To evaluate the short-term therapeutic effects of DNA immunoadsorption(IA) therapy in children with severe systemic lupus erythematosus(SLE).Methods DNA-IA was performed in 12 SLE patients,all scored above 15 in Systemic Lupus Erythematosus Disease Activity Index(SLEDAI) evaluation before treatment and were diagnosed as severely active.Eleven cases received routine DNA-IA therapy of 3 times,while the other case received DNA-IA therapy twice.Levels of anti-nuclear antibody(ANA),ds-DNA,erythrocyte sedimentation rate(ESR),immunoglobulin,complements,blood routine test,hepatic and renal function,and 24h-urinary protein were examined both before and after treatment.Results The symptoms and signs were improved after IA therapy with the SLEDAI scores,ANA titers,anti-ds-DNA antibody levels,ESR,serum IgG,and urinary protein decreased significantly while complement C3 increased on the other hand(P0.05).No significant changes in serum IgA,IgM,C4,blood routine test,hepatic and renal function were noted.No serious complications during the IA process were found.Conclusion DNA-IA is effective in treating children with severe systemic lupus erythematosus and further studies have yet to be carried out to evaluate its long-term effects." @default.
- W2359594492 created "2016-06-24" @default.
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- W2359594492 date "2011-01-01" @default.
- W2359594492 modified "2023-09-26" @default.
- W2359594492 title "Evaluation of Short-Term Therapeutic Effects of DNA Immunoadsorption Therapy in Children with Severe Systemic Lupus Erythematosus" @default.
- W2359594492 hasPublicationYear "2011" @default.
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