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- W2359595990 abstract "Objective: To observe the expression changes of nuclear factor E2 related factor 2(Nrf2)and heme oxygenase-1(HO1) protein in the brains of rats with chronic fluorosis,and so as to reveal the mechanism of brain damage induced by fluorosis. Methods: Ninety SD rats were randomly divided to three groups: control group(group C),fluoride exposure group( group F),fluoride exposure and vitamin E antagonizing group( group FE). The experiment period was 10 months. The fluoride contents in urine and bone were detected by fluoride-ion selective electrode. The protein levels of Nrf2 and HO1 in brains of rats were detected by immunohistochemistry. Results: Dental fluorosis with different degrees was found in group F and group FE,and the former was more serious than the latter( P 0. 05). Fluoride contents in urine and bone in group F and group FE were higher than those of group C,and those in group F were higher than those in group FE(P 0. 05). The levels of Nrf2 and HO1protein in brain tissues in group F and group FE were higher than those of group C,and those in group F were higher than those in group FE(P 0. 05). Conclusions: The expressions of Nrf2 and HO1 in brains of rats with chronic fluorosis are significantly increased,which enhance the antioxidant ability,and may be involved in the brain damages induced by chronic fluorosis." @default.
- W2359595990 created "2016-06-24" @default.
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- W2359595990 date "2014-01-01" @default.
- W2359595990 modified "2023-09-26" @default.
- W2359595990 title "The Expression of Nrf2 and HO1 in the Brains of Rats with Chronic Fluorosis" @default.
- W2359595990 hasPublicationYear "2014" @default.
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