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- W2359596471 abstract "Objective To study the role of polymorphonuclear neutrophils(PMNs)in causing mutiple organ injury and protective effects of pentoxifylline(PTX),an inhibitor of PMNs activating.Methods A rat model of gut ischemia/reperfusion(I/R) was used.Results Gut I/R caused the increase of PMNs sequestration in gut and remote organs of lung and liver,along with the organ injury.However,the changes were markedly reversed by PTX(P0.01).PTX also significantly ameliorated the organs injury(P0.05 or P0.01).Conclusion PMNs sequestration was the main cause for organ injury by gut I/R,PTX can protect the injury,and the mechanism underlying is at least partly due to its inhibition on PMN activating and sequestration." @default.
- W2359596471 created "2016-06-24" @default.
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- W2359596471 date "2009-01-01" @default.
- W2359596471 modified "2023-09-24" @default.
- W2359596471 title "Effects of Pentoxifylline on Organ Injury caused by Gut Ischemia Reperfusion" @default.
- W2359596471 hasPublicationYear "2009" @default.
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