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- W2359607835 abstract "Objective To investigate the expressions of insulin-like growth factor binding protein-5(IGFBP-5)mRNA in the liver and serum leves of IGFBP-5 in patients with liver cirrhosis and primary liver cancer for discussing its clinical significance and its possible association with liver cirrhosis and primary liver cancer.Methods IGFBP-5 mRNA expressions in liver cancer tissues,liver cirrhosis and the adjacent normal tissues(n=8 each) were examined by real-time RT-PCR.Serum levels of IGFBP-5 in patients with cirrhosis(n=21)and primary liver cancer(n=14)and healthy subjects(n=14)were detected by ELISA.The difference of the expressions and serum levels of IGFBP-5 in the mentioned above groups and its clinical significance were analyzed.Results The expressions of IGFBP-5 mRNA in liver tissues and serums levels of IGFBP-5 in patients with cirrhosis were significantly lower than those in matched healthy subjects (all P0.05),and the IGFBP-5 levels in serums were not associated with the high levels of AST,ALT,HA and LN in the same cirrhosis group.Meanwhile,the expressions of IGFBP-5 mRNA in liver tissues and serums levels of IGFBP-5 in patients with primary liver cancer were significantly higher than those in the other two groups (all P0.05),and the IGFBP-5 levels in serums were not associated with the high levels of AST,ALT and AFP in the same cancer group.Conclusions The lower IGFBP-5 expression in the liver cirrhosis patients might be closely associated with the regulation of other cytokines in the liver.While the levels of IGFBP-5 may be a noninvasive examine indicator in the diagnosis of the early liver fibrosis associated with HA and LN.The levels of IGFBP-5 may be a potential examine indicator in the diagnosis of primary liver cancer due to it's high levels in the liver tissues and serums.The further studying about IGFBP-5 may benefit the diagnosis and therapy of liver cirrhosis and primary liver cancer." @default.
- W2359607835 created "2016-06-24" @default.
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- W2359607835 date "2011-01-01" @default.
- W2359607835 modified "2023-09-23" @default.
- W2359607835 title "Levels and clinical significance of insulin-like growth factor binding protein-5 in cirrhosis and primary liver can-cer" @default.
- W2359607835 hasPublicationYear "2011" @default.
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