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- W2359609617 abstract "Objective To explore the effect of chemotherapeutic reagents on the expression of TRAIL receptor DR5 on primary acute leukemia cells.Methods Bone marrow mononuclear cells(BMMNC) from 10 cases of acute leukemia were cultured in vitro in 6 groups:untreated,AcLa treatment,VP-16 treatment,Ara-c treatment,AcLa+Ara-c treatment,and VP-16+Ara-c treatment.After cultured for 72h,the expression of DR5 was analyzed by flow cytometry.Results The expression of DR5 in untreated BMMNC from 10 cases of acute leukemia was low with MFI at 13±4.AcLa and AcLa+Ara-c upregulated the expression of DR5 on BMMNC with MFI at 41±14 and 47±15,respectively.However,the expression of DR5 on BMMNC was not modulated by the treatment of VP-16,Ara-c and VP-16+Ara-c.Conclusion AcLa and AcLa+Ara-c upregulate the expression of DR5 on primary leukemia cells,suggesting that AcLa may exert its anti-leukemia effects by inducing leukemia cell apoptosis mediated by TRAIL induced apoptosis pathway.Ara-c augments the effects of AcLa." @default.
- W2359609617 created "2016-06-24" @default.
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- W2359609617 date "2006-01-01" @default.
- W2359609617 modified "2023-09-23" @default.
- W2359609617 title "Effect of chemotherapeutic reagents on the expression of TRAIL receptor DR5 on primary acute leukemia cells" @default.
- W2359609617 hasPublicationYear "2006" @default.
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