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- W2359609870 abstract "AIM: Since replication-competent retroviruses(RCR) negative is a ma jor consideration for the safe use ofretroviral vectors mediated gene therapy, it is very importantto optimize detection methods of RCR for the clinical applica-tion of retroviral-mediated gene therapy- METHODS: Stud-ies were conducted using retroviral vector pSLXCMV con-taining the gene of anti-HIV-l integrase sFv (pSLXCMV/IN-sFv). The supernatant of PA317 transfected with pSLCMV/IN-sFv was tested using NlH3T3 amplification and S+/L-assay and wild type 4o7OA retroviruses were used as a posi-tive control. RESULTS: No detectable RCR could be foundin the supernatant of PA,,,/IN-sFv cells, while the numberof focus in the positive control was coincided with the 4o7OAvirus titer- CONCLUSION: The results indicate that 'S+/L-assay following NIH3T3 amplification i6 useful in RCR detec-tion and anti-HiV-1 integrase sFv may further be used inclinical trial." @default.
- W2359609870 created "2016-06-24" @default.
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- W2359609870 date "1999-01-01" @default.
- W2359609870 modified "2023-09-23" @default.
- W2359609870 title "Detection of replication-competent retrovirus in retroviral vector mediated gene therapy" @default.
- W2359609870 hasPublicationYear "1999" @default.
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