Matches in SemOpenAlex for { <https://semopenalex.org/work/W2359612824> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W2359612824 abstract "Aim To study the relationship between chiral structure of doxazosin and alfuzosin and their effects on heart rate and contractile force of the isolated mouse atrium.Methods Isolated right and left atria of the mouse were prepared,and the effects of doxazosin,alfuzosin and their enantiomers on the heart rate and contractile force were recorded.Results (+) DOX at 30 μmol·L-1 induced cardiac arrest by 31.3% (5 out of 16) in the isolated right atrium,and(-) DOX and (±) DOX at the same concentration induced cardiac arrest by 8.3% (1 out of 12),respectively.No cardiac arrest was induced in other groups.(+) DOX and (+) DOX at used concentrations decreased the heart rate in a concentration-dependent manner(P0.01),and the inhibition on the heart rate (HR) by (+) DOX was stronger than that by (±) DOX in the isolated right atrium(P0.01).(-) DOX at 10 and 30 μmol·L-1 decreased HR(P0.01),but its effect was weaker than (+) DOX.The HR was mildly decreased by(±) ALF and its enantiomers at 10 and 30 μmol·L-1(P0.05).The contractile force of the isolated left atrium was decreased by (+) DOX at 10 and 30 μmol·L-1 (P0.05),but was increased by (-) DOX at 3 ～30 μmol·L-1(P0.05).The increased force by (-) DOX was stronger than that by (±) DOX(P0.05).(±) ALF and its enantiomers did not affect the contractile force in the isolated left atrium.Conclusion Doxazosin significantly affects the HR and contraction of the isolated mouse atrium,and induces cardiac arrest at high concentration.Chiral structure of doxazosin has an obvious effect on its bioactivity.Alfuzosin,however,decreases the HR mildly without chiral recognition in the isolated mouse atrium." @default.
- W2359612824 created "2016-06-24" @default.
- W2359612824 creator A5087747659 @default.
- W2359612824 date "2010-01-01" @default.
- W2359612824 modified "2023-09-25" @default.
- W2359612824 title "Effects of enantiomers of alfuzosin and doxazosin on heart rate and contractile force in the isolated mouse atrium" @default.
- W2359612824 hasPublicationYear "2010" @default.
- W2359612824 type Work @default.
- W2359612824 sameAs 2359612824 @default.
- W2359612824 citedByCount "0" @default.
- W2359612824 crossrefType "journal-article" @default.
- W2359612824 hasAuthorship W2359612824A5087747659 @default.
- W2359612824 hasConcept C114021368 @default.
- W2359612824 hasConcept C121608353 @default.
- W2359612824 hasConcept C126322002 @default.
- W2359612824 hasConcept C134018914 @default.
- W2359612824 hasConcept C163415756 @default.
- W2359612824 hasConcept C185592680 @default.
- W2359612824 hasConcept C2776235491 @default.
- W2359612824 hasConcept C2777590997 @default.
- W2359612824 hasConcept C2777615863 @default.
- W2359612824 hasConcept C2777953023 @default.
- W2359612824 hasConcept C2779161974 @default.
- W2359612824 hasConcept C2779478474 @default.
- W2359612824 hasConcept C2780546585 @default.
- W2359612824 hasConcept C486523 @default.
- W2359612824 hasConcept C71240020 @default.
- W2359612824 hasConcept C71924100 @default.
- W2359612824 hasConcept C84393581 @default.
- W2359612824 hasConcept C98274493 @default.
- W2359612824 hasConceptScore W2359612824C114021368 @default.
- W2359612824 hasConceptScore W2359612824C121608353 @default.
- W2359612824 hasConceptScore W2359612824C126322002 @default.
- W2359612824 hasConceptScore W2359612824C134018914 @default.
- W2359612824 hasConceptScore W2359612824C163415756 @default.
- W2359612824 hasConceptScore W2359612824C185592680 @default.
- W2359612824 hasConceptScore W2359612824C2776235491 @default.
- W2359612824 hasConceptScore W2359612824C2777590997 @default.
- W2359612824 hasConceptScore W2359612824C2777615863 @default.
- W2359612824 hasConceptScore W2359612824C2777953023 @default.
- W2359612824 hasConceptScore W2359612824C2779161974 @default.
- W2359612824 hasConceptScore W2359612824C2779478474 @default.
- W2359612824 hasConceptScore W2359612824C2780546585 @default.
- W2359612824 hasConceptScore W2359612824C486523 @default.
- W2359612824 hasConceptScore W2359612824C71240020 @default.
- W2359612824 hasConceptScore W2359612824C71924100 @default.
- W2359612824 hasConceptScore W2359612824C84393581 @default.
- W2359612824 hasConceptScore W2359612824C98274493 @default.
- W2359612824 hasLocation W23596128241 @default.
- W2359612824 hasOpenAccess W2359612824 @default.
- W2359612824 hasPrimaryLocation W23596128241 @default.
- W2359612824 hasRelatedWork W1974380793 @default.
- W2359612824 hasRelatedWork W1978714360 @default.
- W2359612824 hasRelatedWork W1982178587 @default.
- W2359612824 hasRelatedWork W2013148631 @default.
- W2359612824 hasRelatedWork W2040205251 @default.
- W2359612824 hasRelatedWork W2043201738 @default.
- W2359612824 hasRelatedWork W2048436132 @default.
- W2359612824 hasRelatedWork W2092762304 @default.
- W2359612824 hasRelatedWork W2286747524 @default.
- W2359612824 hasRelatedWork W2317375739 @default.
- W2359612824 hasRelatedWork W2401234871 @default.
- W2359612824 hasRelatedWork W2409965631 @default.
- W2359612824 hasRelatedWork W2410767837 @default.
- W2359612824 hasRelatedWork W2411815179 @default.
- W2359612824 hasRelatedWork W2416766874 @default.
- W2359612824 hasRelatedWork W2417831611 @default.
- W2359612824 hasRelatedWork W2419523381 @default.
- W2359612824 hasRelatedWork W2895631526 @default.
- W2359612824 hasRelatedWork W2992248717 @default.
- W2359612824 hasRelatedWork W3015065646 @default.
- W2359612824 isParatext "false" @default.
- W2359612824 isRetracted "false" @default.
- W2359612824 magId "2359612824" @default.
- W2359612824 workType "article" @default.