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- W2359619005 abstract "Objective:The human umbilical vein endothelial cells(HUVEC)apoptosis model was established by hydrogen peroxide and intervented by procyanidins(procyanidin).The effect of procyanidins on hydrogen peroxide-induced endothelial cell apoptosis and its mechanism were explored.Methods:The human umbilical vein endothelial cells were cultured and divided into six groups,the control group(Control),oxidative damage group(H2O2),oxidative combined with VitC control group(VC + H2O2),oxidative combined with procyanidins at doses of 5 μmol/L,25 μmol/L,50 μmol/L groups(procyanidin-L + H2O2,procyanidin-M + H2O2,procyanidin-H + H2O2).The 750 μmol/L H2O2 was added to the cells which were cultured with VitC and different concentrations of procyanidins for 24 hours,culturing for 18 hours(cysteine protease expression determination time was 14 hours),acridine orange/ethidium bromide(AO/EB)dual staining microscope observation,Annexin V/ PI flow cytometry were used to detect cell apoptosis,and Western blot was used for analysis of Caspase-3,Bcl-xl and Bax protein expressions.Results:The procyanidins can dose-dependently inhibit H2O2-induced apoptosis of endothelial cells,and significantly lower the expressions of Caspase-3 and Bax protein,significantly up-regulate Bcl-xl protein expression,in a dose-dependent manner,all indicators showed the difference was significant(P0.01).Conclusion:The procyanidins can inhibit vascular endothelial cell apoptosis induced by hydrogen peroxide,which may be related with the down-regulating casapase-3 expression and increasing Bcl-xl/Bax ratio." @default.
- W2359619005 created "2016-06-24" @default.
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- W2359619005 date "2013-01-01" @default.
- W2359619005 modified "2023-09-27" @default.
- W2359619005 title "Inhibition of Procyanidins on the Apoptosis of Human Umbilical Vein Endothelial Cell through the Regulating Caspase-3 and Bcl-xl and Bax" @default.
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