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- W2359632685 abstract "Objective: To investigate the effect of survivin antisense oligodeoxynucleotide(ASODN) transfection on the expression of matrix metalloproteinase(MMP)-2 and MMP-9 in human breast cancer line MCF-7 and to provide experimental foundation for survivin ASODN gene therapy for breast cancer.Methods: Survivin ASODN was transfected into MCF-7 cells through lipofectin.The rate of transfection was detected by fluorescence microscopy.The expressions of survivin,MMP-2 and MMP-9 in transfected cells were detected by RT-PCR and Western blot.Results: Survivin ASODN was successfully transfected into MCF-7 cells.After the transfection,RT-PCR and Western blot analysis revealed that the expressions of survivin,MMP-2 and MMP-9 mRNA and their proteins of antisense group were decreased significantly,compared with the control group.Conclusion: The transfection of survivin ASODN could effectively down-regulate the expressions of survivin,MMP-2 and MMP-9 in MCF-7 cell.Survivin ASODN may provide potential gene therapy for breast cancer." @default.
- W2359632685 created "2016-06-24" @default.
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- W2359632685 date "2011-01-01" @default.
- W2359632685 modified "2023-09-25" @default.
- W2359632685 title "Effect of survivin ASODN transfection on the expression of MMP-2 and MMP-9 in human breast cancer cell" @default.
- W2359632685 hasPublicationYear "2011" @default.
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