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- W2359632916 abstract "Objective:Establishment and evaluation of type 2 diabetic retinopathy model in rats,exploring the efffects of calcium dobesilate on the model.Method: SD rats were randomly divided into normal group and model group,model rats with high fat diet for 3 months,then ip STZ(45 mg·kg-1) one times.12 weeks later,the model rats were randomly divided into model group and drug group.Drug group ig daily calcium dobesilate(150 mg·kg-1).After the administration period,detection of retinal tissue malondialdehyde(MDA),superoxide dismutase(SOD),glutathione(GSH),vascular endothelial growth factor(VEGF),glycosylated of products(AGEs) and other indicators.Result: Compared with model group,drug group SOD activity,VEGF expression are significantly different(P 0.05),but GSH,MDA content and the expression of AGEs was not significantly different.Changes of the aboved index proved that the model was successful.Conclusion: The experimental rat model was established successfully.It may provide a perfect animal model for investigating type 2 diabetic retinopathy and pharmacology successful." @default.
- W2359632916 created "2016-06-24" @default.
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- W2359632916 date "2011-01-01" @default.
- W2359632916 modified "2023-09-25" @default.
- W2359632916 title "Rat Models of Type 2 Diabetic Retinopathy and the Intervention of Calcium Dobesilate on the Model" @default.
- W2359632916 hasPublicationYear "2011" @default.
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