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- W2359632945 abstract "Objective To detect the frequency of blood CD4+CD25+ regulatory T cells(Treg),sereum IFN-γ and IL-4 in patients with chronic obstructive pulmonary disease(COPD),and explore the immunoregulation of Treg in the development of COPD.Methods A flow cytometry was used to detect the frequency of Treg subgroup in 45 patients at acute attacks,33 in remission,and 25 healthy individuals;ELISA was used to determine their serum levels of IL-4 and IFN-γ.Results The level of IL-4 in acute-stage patients was significantly higher that in remission and the control;that in remission was lower than that in healthy controls,the differences being significant(F=192.86,q=11.63-27.66,P0.01).The level of IFN-γ in acute episode was higher than that in remission and the control,the difference being significant(F=35.53;q=9.72,10.13;P0.01),whereas the difference of that between the remission and the control was not significant(q=1.13,P0.05).The proportionality of IFN-γ/IL-4 was the highest in the remission,acute attack came next,and the lowest in healthy controls,with a statistical difference(F=230.95,q=7.79-30.10,P0.01).The frequency of CD4+CD25+ Treg was higher in acute phase than that in clinical remission phase and the control,whereas that in the remission was lower than that of the control(F=146.08,q=8.68-12.72,P0.01).Conclusion There are dynamic changes of Th1/Th2 ratio in patients with COPD: during acute episode,Th2 immunity plays the key role;during remission,it is Th1 that does.Treg plays an important immuno-regulation in the occurrence and development of COPD." @default.
- W2359632945 created "2016-06-24" @default.
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- W2359632945 date "2011-01-01" @default.
- W2359632945 modified "2023-09-23" @default.
- W2359632945 title "DETECTION OF CD4~+CD25~+REGULATORY T CELLS IN PERIPHERAL BLOOD OF COPD PATIENTS" @default.
- W2359632945 hasPublicationYear "2011" @default.
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