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- W2359637413 abstract "AIM: To investigate whether the panaxadiol saponins( PDS) and dexamethasone( DEX) have similar effects on lipopolysaccharide( LPS)-induced acute kidney injury( AKI). METHODS: C57BL /6 mice were randomly divided into 4 groups: the control mice received intraperitoneal injection of normal saline; in LPS group,the mice were subjected to intraperitoneal injection of LPS( 10 mg / kg); in PDS + LPS group and DEX + LPS group,the mice were injected intraperitoneally with PDS( 25. 0 mg / kg) and DEX( 2. 5 mg / kg) 1 h before LPS injection,respectively. The blood was collected from the hearts,and the kidneys were collected for the biochemical and Western blotting analysis 12 h after LPS injection. RESULTS: LPS induced AKI,evidenced by markedly increased blood urea nitrogen( BUN) and creatinine( CREA) contents compared with control group( P 0. 01). However,serum contents of CREA and BUN obviously reduced in PDS + LPS group and DEX + LPS groups compared with LPS group( P 0. 05). Both PDS and DEX decreased the production of TNF-α and IL-6 by inhibiting renal NF-κB signaling activation. PDS and DEX also down-regulated the expression of inducible nitric oxide synthase,up-regulated the expression of manganese superoxide dismutase and reduced oxidative stress in the kidneys of LPS-challenged mice. In addition,treatment with PDS and DEX significantly increased the nuclear glucocorticoid receptor in the kidneys of LPS-treated mice. CONCLUSION: PDS and DEX have inhibitory effects on LPS-induced AKI mice. However,it is unclear whether PDS reduces LPS-induced AKI via direct action on glucocorticoid receptor." @default.
- W2359637413 created "2016-06-24" @default.
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- W2359637413 date "2014-01-01" @default.
- W2359637413 modified "2023-09-23" @default.
- W2359637413 title "Panaxadiol saponins and dexamethasone have similar actions on LPS-induced AKI in mice" @default.
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