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- W2359645842 abstract "Objective:To study preserve effect and mechanisms of erythropoietin(EPO) on spatial learning and memory in chronic cerebral ischemic rats.Methods:The chronic cerebral ischemia models were made by permanent bilateral occlusion of both common carotid arteries(2VO).After the surgery,rats were routinely bred for 3month,1000U/kg EPO was intraperitoneal injected for 1 week.3 weeks later,Morris water maze test was carried out to evaluate the spatial learning and memory,immunohistochemistry and immunofluorescence were used to study apoptosis and cell proliferation in hippocampal dentate gyrus.Results: Chronic cerebral ischemia could induce spatial learning and memory impairment,P0.01,administration of EPO can improve rats performance in water maze,P0.05.Results from immunofluorescence indicate that chronic cerebral ischemia induced cell apoptosis in hippocampal dentate gyrus,(19.50±3.52)/0.1 mm2 VS(9.58±2.43)/0.1 mm2,P0.01,rats received EPO treatment with less apoptosis cells than saline-treated rats,(13.17±2.25)/0.1 mm2 VS(19.50±3.52)/0.1 mm2,P0.05.Immunohistochemisty results revealed that chronic cerebral ischemia could promote cell proliferation in surgical rats,(6.46±0.82)/0.1 mm2 VS(3.59±0.73)/0.1 mm2,P0.05,the phenomenon was more obvious in EPO treated rats,(8.24±0.89)/0.1 mm2 VS(6.46±0.82)/0.1 mm2,P0.05.Conclusions: EPO relieves hypoperfusion induced spatial learning and memory impairment by promote cell proliferation and reduce cell apoptosis in chronic cerebral ischemia rats." @default.
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- W2359645842 date "2011-01-01" @default.
- W2359645842 modified "2023-09-26" @default.
- W2359645842 title "Mechanisms of Erythropoietin relieve hypoperfusion induced spatial learning and memory impairment in chronic cerebral ischemic rats" @default.
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