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- W2359647924 abstract "OBJECTIVE To study the preparation of melanoma vaccine formulated with membrane fusogenic liposome and evaluate the cellular and systemic immune responses in immunized mice.METHODS The antigen,mixed protein extracted from B 16 melanoma cell,was encapsulated in membrane fusogenic liposomes prepared by fusing simple liposomes with Sendai virus.The liposomes were characterized for their sizes and shapes by laser light granule analysis instrument and transmission electron microscope.The cytotoxic T lymphocyte (CTL) response level was evaluated by 51 Cr release method,and the concentration of IgG in serum was measured by enzyme immunoassay.RESULTS The vaccine formulated with simple liposomes or free protein induced systemic response,but did not induce CTL response.However,melanoma vaccine formulated with membrane fusogenic liposome elicited not only systemic immune response but also strong CTL response ( P 0.001),and inhibited the growth of tumor.CONCLUSION Membrane fusogenic liposomes is effective as a vector for anti tumor vaccine." @default.
- W2359647924 created "2016-06-24" @default.
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- W2359647924 date "2003-01-01" @default.
- W2359647924 modified "2023-09-25" @default.
- W2359647924 title "Study on melanoma vaccine using membrane fusogenic liposomes as the vector" @default.
- W2359647924 hasPublicationYear "2003" @default.
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