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- W2359652805 abstract "Objective To investigate the estrogen-like effects of Epimedium extractive.Methods By using the uterus growth test in mice and test of MCF-7 proliferation and adding estrogen receptor antagonist Icariin,we evaluated the estrogenic effects of Epimedium and Icariin and the possible mechanism.Results Epimedium and Icariin increased significantly the uterus coefficient in mice from 0.097±0.008 to 0.156±0.018 and 0.152±0.016,respectively;the weight increased significantly from(18.9±1.3)g to(19.8±1.3)g and(20.03±1.3)g(P0.05).Icariin increased significantly the serum level of E2 from(132.22±11.45)ng/L to(147.73±12.43)ng/L and decreased FSH level from(50.15±3.36)μg/L to(44.47±2.46)μg/L(P0.05),but there was no significant difference in Epimedium group.There was obviously enhanced proliferation in MCF-7 in 24,48 and 72 h (P0.05),from 0.238±0.043,0.387±0.051 and 0.563±0.083 to 0.362±0.045,0.521±0.046 and 0.648±0.043 as well as 0.324±0.043,0.465±0.034 and 0.622±0.079,respectively.However,the cell proliferation was inhibited significantly by Icariin added in 72 h,the proliferation ratio decreased to 99.461% and 94.434%,respectively.Conclusion Epimedium and Icariin have estrogen-like effects and all of their effects are realized through the estrogen receptor." @default.
- W2359652805 created "2016-06-24" @default.
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- W2359652805 date "2009-01-01" @default.
- W2359652805 modified "2023-09-23" @default.
- W2359652805 title "Study on the estrogen-like effects of Epimedium extractive" @default.
- W2359652805 hasPublicationYear "2009" @default.
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