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- W2359653596 abstract "Objective The purpose of this study was to evaluate the effect of nifedipine,the calcium channel blocker,on myocardial contractile changes induced by low K~+ perfusion. Methods Isolated rat hearts were perfused with modified KH solution containing 3.1 mmol/L K~+.The left ventricular developed pressure(LVDP),left ventricular end-diastolic pressure(LVEDP),and dp/dt of left ventricle were monitored. Results After 1 h ischemia/1 h reperfusion,there were a marked decrease in LVDP and dp/dt,and an increase in LVEDP.Perfusion with 0.5 mmol/L Ca~2+ during the first 15 min reperfusion significantly improved the contractile dysfunction.However,nifedinpine,which was given during the first 10 min reperfusion,significantly increased the level of LVEDP.In addition,nifedinpine produced a trend of decrease in LVDP and dp/dt,although no statistical significance. Conclusion Those results confirmed that calcium overload mediates ischemia/reperfusion-induced contractile dysfunction in heart perfusing with low potassium,and also suggested that nifedipine produces exacerbated effect on the ischemic heart." @default.
- W2359653596 created "2016-06-24" @default.
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- W2359653596 date "2012-01-01" @default.
- W2359653596 modified "2023-09-24" @default.
- W2359653596 title "Nifedipine worsens recovery of diastolic function after ischemia/reperfusion in heart perfused with low K~+ buffer" @default.
- W2359653596 hasPublicationYear "2012" @default.
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